INTRODUCTION The number people affected by malaria is increasing enormously. This increasing is due to the novel drug resistant variants of the parasite that causes malaria the Plasmodium. This resistance is a consequence of the massive use of the quinoline-related drugs over the last decades. In this scenario, it became important to search for new drugs, active against novel biochemical parasite targets. The drug known as artemisin or Qinghaosu (1), is a result of Chinese government …showed first 75 words of 869 total…

…showed last 75 words of 869 total…Amadeu, not only for the contribution that made this great opportunity happen, but also for all patience, assistance and knowledge given me during the last year. Dr. Storr and Dr. Paul O’Neill whose kindness, sympathy, comprehension and support, made this dream possible. Rui, Ricardo, Steve, Vick, Tatiana and Ollie for all the help and friendship. I also would like to thank to the University of Liverpool for allowing me to use all the facilities.